"Brugge and her research team have analyzed the cell structure of more than 100 samples. Using high-powered microscopes and complex computer algorithms, they diagram each stage in the development of breast cancer: from the first sign of cell mutation to the formation of tiny clusters, well before they are large enough to be considered tumors. Their quest is to prevent breast cancer, a disease that afflicts roughly 1 in 8 U.S. women over their lifetimes, as well as some men."
"In late 2024, Brugge and her colleagues identified specific cells in breast tissue that contain the genetic seeds of breast tumors. And they discovered that these "seed cells" are surprisingly common. In fact, they are present in the normal, healthy tissue of every breast sample her lab has examined, Brugge said, including samples from patients who haven't had breast cancer but have had surgery for other reasons, such as breast reduction or a biopsy that proved benign."
Researchers analyzed more than 100 donated breast tissue samples, using high-powered microscopes and computational algorithms to map cellular changes from initial mutation to tiny pre-tumor clusters. The team identified specific cells that carry genetic alterations that can seed breast tumors. These "seed cells" appeared in normal, healthy tissue across all examined samples, including those from people without breast cancer. The multiyear study, supported by a seven-year federal grant, aims to prevent breast cancer by detecting and targeting early cellular events before tumors form.
Read at Truthout
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