"The results, published today in Nature, reveal that people with seemingly disparate conditions often share many of the same disease-linked genetic variants. The analysis found that 14 major psychiatric disorders cluster into five categories, each characterized by a common set of genetic risk factors. The neurodevelopmental category, for example, includes both attention deficit hyperactivity disorder and autism, which psychiatric handbooks classify as separate conditions."
"To learn whether there is a biological explanation for these correlations, Grotzinger and his colleagues aggregated genomic data from more than one million people with psychiatric conditions and from millions of healthy controls. The researchers found that the 14 mental-health conditions they studied generally fall into five distinct buckets, each with its own genetic profile. There's a schizophrenia/bipolar disorder category;"
A genetic analysis of over one million people and millions of controls identifies widespread genetic overlap among psychiatric conditions. Fourteen major disorders group into five genetically defined categories, each sharing characteristic risk variants. The neurodevelopmental group combines attention-deficit hyperactivity disorder and autism. Schizophrenia and bipolar disorder cluster together, while other categories reflect internalizing and additional shared profiles. High rates of comorbidity among diagnoses correspond with shared biological risk, suggesting diagnostic boundaries are less distinct than presumed. Aggregating large genomic datasets clarifies the genetic architecture of mental-health conditions and points toward more integrated approaches to diagnosis and potentially to treatment.
Read at Nature
Unable to calculate read time
Collection
[
|
...
]