Evidence Based Medicine was formalized in the 1990s, largely by Canadian physician David Sackett. Sackett described the goal of EBM is to replace hunches and habits with data and clinical trials. Clinical guidelines were developed involving protocols that tell doctors which drug to prescribe first, what dose to use, when to escalate treatment, and when to refer a patient to a specialist.
When Lola was eight years old, she went through a massive growth spurt and started developing acne. Her mother, Elise, thought Lola was just growing fast because of genes inherited from her father. But when she noticed that Lola had grown pubic hair too, she was floored. A visit to an endocrinologist in 2023 confirmed that Lola's brain was already producing hormones that had kick-started puberty.
Clinical guidelines should no longer recommend Prozac for children, according to experts, after research showed it had no clinical benefit for treating depression in children and adolescents. Globally one in seven 10-19 year olds have a mental health condition, according to the World Health Organization. In the UK, about a quarter of older teenagers and up to a fifth of younger children have anxiety, depression or other mental health problems.