#colibactin

#colibactin

Colibactin from common gut bacteria forms inter-strand DNA cross-links that induce severe DNA damage, promoting chromosome breaks and mutations linked to colorectal cancer.

Colorectal cancer has doubled in individuals under 55, potentially linked to the colibactin toxin produced by E. coli.

The majority of younger colorectal cancer patients exhibit mutations associated with past colibactin exposure.