#microglia

[ follow ]
fromNature
1 week ago

Swapping old immune cells in the brain with fresh ones could treat disease

A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer's disease. In the past few months, a spate of new studies have highlighted the potential of a technique called microglia replacement and explored ways to make it safer and more effective. "This approach is very promising," says Pasqualina Colella, who studies gene and cell therapy at Stanford University School of Medicine in California. "But the caveat is the toxicity of the procedure."
Science
Medicine
fromScienceDaily
1 week ago

Brain fat, not just plaques, may be the hidden driver of Alzheimer's

Excess fat accumulation in microglia impairs their protective function in Alzheimer's, and breaking down that fat restores brain immune defenses.
Mental health
fromPsychology Today
3 weeks ago

Rethinking Depression: Beyond Chemical Imbalance

Major depression involves altered chromatin accessibility in specific brain cell types, indicating gene-regulation rewiring rather than only a simple chemical imbalance.
Medicine
fromwww.nature.com
1 month ago

Microglianeuron crosstalk via HexGM2MGL2 maintains brain homeostasis

Microglia deliver lysosomal enzyme -hexosaminidase to neurons, aiding the degradation of ganglioside GM2 essential for neuronal health.
Mental health
fromHarvard Gazette
5 months ago

Immune-system strategy used to treat cancer may help with Alzheimer's - Harvard Gazette

Inhibiting TIM-3 in mice enhances microglial activity against Alzheimer's plaques, potentially restoring memory function.
[ Load more ]