#tdp-43

#tdp-43

They focused on UPF1, a protein that acts like a proofreader, scanning RNA and destroying defective copies before they cause trouble. This process, called mRNA decay, is essential for healthy cells. The team discovered that UPF1 and TDP-43 normally work together to control the length of RNA messages - especially at their tail ends. These regions help regulate how long an RNA message lasts and where it goes in the cell. In ALS, these processes go haywire, leading to unstable RNA and stressed neurons.