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Sperm donor with rare cancer mutation fathered nearly 200 children in Europe

A sperm donor carrying a germline TP53 mutation has fathered at least 197 children across 14 European countries, placing many offspring at high cancer risk.

Medicine

fromNature

3 months ago

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature

Disrupting the cyclin A–E2F1 interaction selectively induces apoptosis in RB1/TP53-deficient small cell lung cancer, offering a synthetic lethal therapeutic strategy.

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Sperm donor with rare cancer mutation fathered nearly 200 children in Europe

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature

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#tp53