"The study, which analyzed electronic health record data from 40 children's hospitals and health systems across the United States, found that young patients who experienced a second confirmed SARS-CoV-2 infection during the omicron period were more than twice as likely to receive a clinician-documented diagnosis of post-acute sequelae of COVID-19 (PASC) as those in the same calendar period after a first infection."
"Earlier work helped define long COVID in children after a first infection, but once omicron became dominant and reinfections became routine, a pressing clinical question emerged: does getting COVID a second time carry its own distinct risk of long COVID, or does prior infection confer meaningful protection? Existing pediatric evidence was thin, mostly based on small survey-based studies with self-reported outcomes and limited ability to control for confounders."
"The cohort included more than 465,000 patients younger than 21 years with at least one documented SARS-CoV-2 infection after January 1, 2022. Within this cohort, roughly 407,300 patients were analyzed after a first infection and 58,417 were analyzed after a second infection occurring at least 60 days after the first."
"Over a six-month follow-up period, the incidence of clinician-documented PASC was roughly 1,884 cases per million children after a second infection, compared with about 904 cases per million after a first infection. After adjusting for demographic characteristics, underlying health con"
Children and adolescents reinfected with SARS-CoV-2 during the omicron period show a higher risk of post-acute sequelae of COVID-19. Electronic health record data from 40 children’s hospitals and health systems in the United States were used to compare outcomes after first versus second confirmed infections. The cohort included more than 465,000 patients younger than 21 years with at least one documented infection after January 1, 2022. About 407,300 patients were analyzed after a first infection, and 58,417 were analyzed after a second infection occurring at least 60 days later. Over six months, clinician-documented PASC occurred at roughly 1,884 cases per million after reinfection versus about 904 cases per million after first infection. Adjustments for demographics and underlying health factors supported the increased risk.
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