An experimental male contraceptive pill, YCT-529, has successfully passed its first human safety trial. This hormone-free pill prevents sperm production by blocking vitamin A in the testes without affecting testosterone levels or libido. The initial trials involved 16 men, all of whom had undergone vasectomies, to identify any side effects, and results showed no significant changes in heart rate, hormones, mood, or sexual function. Future trials will assess the pill's efficacy in preventing sperm production in humans, and it is anticipated to be available in the coming decade.
YCT-529, an experimental male contraceptive pill, blocks sperm production by preventing access to vitamin A in testes while leaving testosterone levels and libido unchanged.
The recent human safety trial of YCT-529 revealed no concerning changes in heart rate, hormone function, inflammation, mood, or sexual function among participants.
Experts emphasize a need for more reversible contraceptive methods for men, highlighting that current options are limited primarily to vasectomies and condoms.
YCT-529 has shown 99 percent effectiveness in preventing pregnancies in prior mouse studies and aims to be available for human use in the near future.
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