#cd8-t-cells

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#breastfeeding #transcription-factors #t-cell-exhaustion #tissue-resident-memory #adoptive-cell-therapy
Medicine
fromNature
18 hours ago

Atlas-guided discovery of transcription factors for T cell programming - Nature

Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
Medicine
fromNature
3 months ago

Breastfeeding boosts immune cells that protect against breast cancer

Pregnancy and breastfeeding trigger long-lived CD8+ T cell accumulation in breast tissue, lowering breast cancer risk and producing lasting immune protection.
fromwww.nature.com
3 months ago
Cancer

Parity and lactation induce T cell mediated breast cancer protection

Parity and breastfeeding reduce breast cancer risk, notably TNBC, and parity induces accumulation of CD8+ tissue-resident memory-like T cells in normal breast tissue.
Medicine
fromwww.theguardian.com
3 months ago

Protective immune cells in breastfeeding women identified as guard against breast cancer, new research finds

Breastfeeding induces long-lasting CD8 T-cell residency in breast tissue that provides durable adaptive immune protection against breast cancer.
Medicine
fromNature
4 months ago

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 - Nature

Dietary cysteine enhances intestinal stem cell regeneration after injury by supporting CoA biosynthesis, expanding intraepithelial CD8αβ+ T cells, and increasing IL-22 signaling.
fromNews Center
4 months ago

Molecular Mechanisms Support Long-term Immunity - News Center

Scientists in the laboratory of Weiguo Cui, PhD, professor of Pathology in the Division of Experimental Pathology, have identified novel molecular mechanisms that help specialized T-cells maintain long-term immunity in response to chronic infection and cancer, according to recent findings published in Nature Immunology. Previous work from Cui's laboratory and others revealed that exhausted T-cells, or T-cells that have become dysfunctional after chronic antigen stimulation such as chronic infection and cancer, comprise different subgroups of T-cells.
Science
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