#precision-medicine

#precision-medicine

Northwestern University has launched the Simpson Querrey Brain Health Institute (SQ-Brain), made possible by nearly $25 million in philanthropic funding from university trustee Kimberly K. Querrey ('22, '23 P). SQ-Brain envisions a future where our brains last as long as our bodies a world where brain health is continuously measurable, modifiable and monitorable across the lifespan, and where prevention of cognitive decline and brain injury is anchored in neurovascular biology and precision medicine.

Just as there have been remarkable advances in weather forecasting with the use of large language models, so will there be for determining an individual's risk of the major age-related diseases (cancer, cardiovascular, and neurodegenerative). These diseases share common threads, such as a long incubation phase before any symptoms are manifest, usually two decades or more. They also have the same biologic underpinnings of immunosenescence and inflammaging, terms that characterize an immune system that has lost some of its functionality

A whole slew of next-generation obesity drugs are on the horizon, some already advanced enough in clinical trials to be looking as good as-if not better than-those already on the market. The novel medications continue to push the upward limits of weight loss, now to almost 25 percent of body weight on average, but they also differ in their modes of action. They target different cells and different parts of cells in the brain and body.

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