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1 week agoDesign of facilitated dissociation enables timing of cytokine signalling - Nature
Protein-protein interactions orchestrate much of biological function. High-affinity interactions enable protein circuits to respond to low concentrations of stimuli and to act potently on targets; fast exchange enables them to respond quickly to changes in stimuli. These two properties cannot usually be achieved simultaneously in binary interactions because they depend on the interaction off-rate in opposite ways: high affinity usually requires slow dissociation (low off-rate), whereas rapid exchange requires fast dissociation (high off-rate) (Supplementary Fig. 1).
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